Table 4.
The role of lncRNAs and miRNAs in NKTL.
| Noncoding RNA | Encoded by EBV (Yes/No) | Target gene | Underexpressed Overexpressed in NKTL | Biological significance | References |
|---|---|---|---|---|---|
| BART9 | Yes | LMP-1 | Overexpressed | BART9 is involved in NKTL proliferation by regulating LMP-1 levels | 79 |
| miR-BART20-5p | Yes | T-bet(TBX21) | – | promotes NKTL progress via the PTEN-AKT-mTOR/RICTOR pathway | 85 |
| miR-BART20-5p | Yes | – | – | promotes the development of NKTL through inhibition of the IFN-γ-STAT1 pathway | 78 |
| miR-BART8 | Yes | – | – | causes progression of NKTL through inhibition of the IFN-γ-STAT1 pathway | 78 |
| miR-142-3p | No | IL1-a | Underexpressed | regulates the expression of IL1A | 85 |
| lncRNA MALAT1 | No | ZH2, SUZ12 | Overexpressed | MALAT1 is related to poor prognosis | 91 |
| miR-21,miR155 | No | – | Overexpressed | leads to activation of the PI3K-AKT pathway | 82 |
| miR-150 | No | AKT2, DCK1 | Underexpressed | induces continuous activation of the PI3K-AKT pathway | 86 |
| miRNA-146a | No | TRAF6 | Underexpressed | downregulates NF-κB activity and is related to prognosis | 87 |
| miR-15a | No | Myb, cyclin D1 | Underexpressed | promotes cell proliferation and predicts poor prognosis in NKTL | 94 |
| miR-223 | No | PRDM1 | Overexpressed | The downregulation of the tumour suppressor PRDM1 is mediated by miR-223 and that PRDM1-positive staining might have prognostic value for NKT patients | 92 |
| miR-155 | No | BRG1 | Overexpressed | activates STAT3/VEGFC signaling, promotes lymphangiogenesis and controlled the viability of NKTCL cells | 84 |
| miR-155 | No | Foxo3a | – | Reduction in miRNA-155 expression can inhibit the proliferation of SNK-6 lymphoma cells and promote their apoptosis | 89 |
| miR-494-3p | No | PTEN | Overexpressed | promotes NKTL progress through the PTEN-AKT-mTOR/RICTOR pathway | 85 |
| miR-142-3p | No | RICTOR | Overexpressed | inhibites RICTOR, with secondary suppression of AKT in YT cells | 80 |
| circulating miR-221 | No | – | – | a reverse correlation with performance status and the overall survival after treatment | 101 |
| miR-16 | No | Bmi1 | Underexpressed | enhances p21 expression via downregulation of Bmi1, thereby inducing cellular senescence | 102 |
| miR-205 | No | BCL6 | Underexpressed | regulates the expression of the oncogenic BCL6 | 80 |
| miR-34a,miR-181c | No | PDGFRα | – | are involved in the oncogenic progression of NKTL through the regulation of PDGFRα, STAT3, and K-RAS | 88 |
| miR-143,miR-20b, miR34a | No | – | – | miR-20b, miR34a, miR-143 expression showed inverse correlations with STAT3 mRNA expression in NKTCL tissues | 99 |