FIGURE 4.

Treatment effects on hippocampal-dependent memory on a novel COD task. (a) When tested between a context-congruent and -incongruent object, microglial depleted rats had worse memory than control (p <.01) and microglial replenished rats (p <.05). (b) More specifically, rats did not vary on the amount of time they explored the context-congruent object, but treatment impacted the percentage of time they explored the context-incongruent object, with control rats exploring it more than microglial depleted (p <.01) and replenished (p = .02) rats. Moreover, controls and microglial replenished rats exhibited a heightened preference for the context-incongruent object over the context-congruent object. All data are represented as means ± SEM (N = 7–10 young/treatment; N = 6–7 aged/treatment). ## p ≤.01, control versus microglial depleted; & p ≤.05, control versus microglial replenished; * p ≤.05, microglial depleted versus microglial replenished; $ p ≤.05, $ $ p ≤.01, $ $ $, p ≤.001, congruent versus incongruent object