Comparison 1. Laparoscopic fundoplication versus medical management.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Health‐related quality of life (< 1 year)	3	605	Std. Mean Difference (IV, Fixed, 95% CI)	0.14 [‐0.02, 0.30]
2 Health‐related quality of life (1 to 5 years)	2	323	Std. Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.19, 0.24]
3 GORD‐specific quality of life (< 1 year)	4	1160	Std. Mean Difference (IV, Fixed, 95% CI)	0.58 [0.46, 0.70]
4 GORD‐specific quality of life (1 to 5 years)	3	994	Std. Mean Difference (IV, Random, 95% CI)	0.28 [‐0.27, 0.84]
5 Serious adverse events	2	637	Risk Ratio (M‐H, Fixed, 95% CI)	1.46 [1.01, 2.11]
6 Adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7 Dysphagia (< 1 year)	2	637	Risk Ratio (M‐H, Fixed, 95% CI)	3.58 [1.91, 6.71]
8 Dysphagia (1 to 5 years)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9 Dysphagia (5 years or more)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10 Heartburn (< 1 year)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
11 Heartburn (1 to 5 years)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
12 Heartburn (5 years or more)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
13 Reflux (< 1 year)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
14 Reflux (1 to 5 years)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
15 Reflux (5 years or more)	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected