Table 7.
Associations between urine biomarkers of chemical exposure and specific IgEd in adult participants
| Sex: male vs female | Specific IgEd | Interactionc | |||||
|---|---|---|---|---|---|---|---|
| ∆/OR | CI | p | ∆/OR | CI | p | p | |
| Sum of parabena | -0.66 | (-0.80,-0.51) | < 0.001 | -0.08 | (-0.06,0.23) | 0.3 | 0.03 |
| Methylparabena | -1.68 | (-2.02,-1.34) | < 0.001 | 0.22 | (-0.11,0.55) | 0.3 | 0.2 |
| Butylparabenb | 0.14 | (0.09,0.25) | < 0.001 | 0.66 | (0.42,1.03) | 0.07 | 0.5 |
| Propylparabena | -2.14 | (-2.51,-1.77) | < 0.001 | 0.07 | (-0.31,0.45) | 0.7 | 0.5 |
| Ethylparabena | -1.06 | (-1.35,-0.76) | < 0.001 | -0.06 | (-0.36,0.23) | 0.4 | 0.7 |
| Benzophenone-3a | -1.54 | (-1.94,-1.14) | < 0.001 | -0.23 | (-0.63,0.18) | 0.3 | 1.0 |
| Bisphenol Sa | -0.09 | (-0.22,0.04) | 0.2 | 0.18 | (-0.04,0.32) | 0.01 | 0.3 |
| Bisphenol Fa | -0.13 | (-0.33,0.06) | 1.3 | -0.02 | (-0.22,0.18) | 0.8 | 0.1 |
| Bisphenol Aa | 0.19 | (0.04,0.34) | 0.01 | 0.11 | (-0.04,0.26) | 0.1 | 0.4 |
| 2,4- DCPa | -0.06 | (-0.19,0.08) | 0.4 | 0.15 | (-0.01,0.29) | 0.03 | 0.6 |
| 2,5 –DCPb | 1.89 | (1.24 2.88) | 0.03 | 0.84 | (0.57,1.24) | 0.4 | 0.9 |
| Triclosanb | 0.74 | (0.46,1.19) | 0.2 | 1.05 | (0.67,1.63) | 0.8 | 0.06 |
| Triclocarbanb | 0.68 | (0.27,1.70) | 0.4 | 1.06 | (0.39,2.10) | 0.4 | 0.3 |
aMultiple linear or blogistic regression including sex and variable for IgE, adjusted for BMI, age, smoking, and time of day of urine sampling. c Interaction term between sex and IgE. dIgE positivity defined by IgE ≥ 0.35 kU/L to at least 1 of 5 allergens tested (cat, timothy grass, Cladosporium, birch, and house dust)