Table 2.
Estimated hazard ratios for covid-19 outcomes among adults ≥16 years and children <16 years adjusted for potential confounders (age, sex, ethnicity, geographical region)
| Exposure category | Covid-19 related hospital admission | Covid-19 related death | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Events | Person years | Crude rate* (95% CI) | Hazard ratio (95% CI) | Events | Person years | Crude rate* (95% CI) | Hazard ratio (95% CI) | ||
| Wave 1: adults (≥16 years) | |||||||||
| Learning disability register | |||||||||
| No | 29 781 | 7 133 803 | 4.2 (4.1 to 4.2) | Reference | 13 737 | 7 140 988 | 1.9 (1.9 to 2.0) | Reference | |
| Yes | 538 | 45 126 | 11.9 (11.0 to 13.0) | 5.30 (4.85 to 5.80) | 222 | 45 257 | 4.9 (4.3 to 5.6) | 8.21 (7.15 to 9.42) | |
| Severity (learning disability register) | |||||||||
| Mild | 391 | 37 070 | 10.5 (9.6 to 11.6) | 4.74 (4.30 to 5.23) | 159 | 37 167 | 4.3 (3.7 to 5.0) | 7.15 (6.12 to 8.34) | |
| Profound | 147 | 8056 | 18.2 (15.5 to 21.4) | 7.75 (6.43 to 9.33) | 63 | 8090 | 7.8 (6.1 to 10.0) | 13.14 (9.94 to 17.39) | |
| Residential care status | |||||||||
| Not in residential care | 438 | 41 141 | 10.6 (9.7 to 11.7) | 4.87 (4.44 to 5.34) | 182 | 41 249 | 4.4 (3.8 to 5.1) | 7.81 (6.77 to 9.02) | |
| In residential care | 100 | 3984 | 25.1 (20.6 to 30.5) | 8.72 (6.77 to 11.25) | 40 | 4008 | 10.0 (7.3 to 13.6) | 10.65 (7.08 to 16.03) | |
| Down’s syndrome | |||||||||
| No | 30 244 | 7 174 961 | 4.2 (4.2 to 4.3) | Reference | 13 918 | 7 182 261 | 1.9 (1.9 to 2.0) | Reference | |
| Yes | 75 | 3968 | 18.9 (15.1 to 23.7) | 10.59 (8.47 to 13.23) | 41 | 3983 | 10.3 (7.6 to 14.0) | 36.34 (26.67 to 49.51) | |
| Cerebral palsy | |||||||||
| No | 30 221 | 7 169 773 | 4.2 (4.2 to 4.3) | Reference | 13 929 | 7 177 063 | 1.9 (1.9 to 2.0) | Reference | |
| Yes | 98 | 9156 | 10.7 (8.8 to 13.0) | 4.95 (3.86 to 6.36) | 30 | 9181 | 3.3 (2.3 to 4.7) | 5.83 (4.12 to 8.26) | |
| Wave 1: children (<16 years) | |||||||||
| Learning disability register | |||||||||
| No | >200† | 1 318 599 | 0.2 (0.2 to 0.2) | Reference | —‡ | —‡ | —‡ | —‡ | |
| Yes | ≥5† | 4700† | 1.1 (0.4 to 2.6) | 6.21 (2.75 to 14.05) | —‡ | —‡ | —‡ | —‡ | |
| Wave 2: adults (≥16 years) | |||||||||
| Learning disability register | |||||||||
| No | 63 053 | 6 262 945 | 10.1 (10.0 to 10.1) | Reference | 19 778 | 6 270 857 | 10.1 (10.0 to 10.1) | Reference | |
| Yes | 1004 | 40 002 | 25.1 (23.6 to 26.7) | 4.32 (4.05 to 4.61) | 286 | 40 121 | 25.1 (23.6 to 26.7) | 7.22 (6.41 to 8.13) | |
| Severity (learning disability register) | |||||||||
| Mild | 722 | 32 856 | 22 (20.4 to 23.6) | 3.82 (3.55 to 4.11) | 197 | 32 943 | 22.0 (20.4 to 23.6) | 6.07 (5.29 to 6.96) | |
| Profound | 282 | 7146 | 39.5 (35.1 to 44.3) | 6.52 (5.77 to 7.37) | 89 | 7177 | 39.5 (35.1 to 44.3) | 12.42 (10.06 to 15.33) | |
| Residential care status | |||||||||
| Not in residential care | 813 | 36 637 | 22.2 (20.7 to 23.8) | 3.92 (3.64 to 4.21) | 231 | 36 735 | 22.2 (20.7 to 23.8) | 6.73 (5.91 to 7.66) | |
| In residential care | 191 | 3365 | 56.8 (49.3 to 65.4) | 7.73 (6.51 to 9.19) | 55 | 3385 | 56.8 (49.3 to 65.4) | 10.37 (7.61 to 14.12) | |
| Down’s syndrome | |||||||||
| No | 63 898 | 6 299 465 | 10.1 (10.1 to 10.2) | Reference | 19 998 | 6 307 480 | 10.1 (10.1 to 10.2) | Reference | |
| Yes | 159 | 3482 | 45.7 (39.1 to 53.3) | 9.66 (8.28 to 11.27) | 66 | 3498 | 45.7 (39.1 to 53.3) | 38.50 (30.13 to 49.18) | |
| Cerebral palsy | |||||||||
| No | 63 865 | 6 294 857 | 10.1 (10.1 to 10.2) | Reference | 20 030 | 6 302 862 | 10.1 (10.1 to 10.2) | Reference | |
| Yes | 192 | 8,090 | 23.7 (20.6 to 27.3) | 4.23 (3.67 to 4.87) | 34 | 8116 | 23.7 (20.6 to 27.3) | 4.40 (3.14 to 6.17) | |
| Wave 2: children (<16 years) | |||||||||
| Learning disability register | |||||||||
| No | 509 | 1 137 827 | 0.4 (0.4 to 0.5) | Reference | —‡ | —‡ | —‡ | —‡ | |
| Yes | 20 | 4152 | 4.8 (3.1 to 7.5) | 9.18 (5.89 to 14.29) | —‡ | —‡ | —‡ | —‡ | |
Wave 1: 1 March 2020-31 August 2020; wave 2: 1 September 2020-8 February 2021.
*
Per 1000 person years.
†
Rounded to avoid inadvertent disclosure of small event numbers. Median person years (25th-75th percentile): 0.504 (0.504 to 0.504) in wave 1 and 0.44 (0.44 to 0.44) in wave 2 for children and adults.
‡
Insufficient events for analysis.