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. 2021 Jul 13;19:209. doi: 10.1186/s12951-021-00958-6

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© The Author(s) 2023, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Exosomal miR-1260a promotes osteogenesis and angiogenesis by targeting HDAC7 and COL4A2. (**) p < 0.01, (***) p < 0.001, ns = no significance; NC, negative control. a The red staining indicative of mineralization is most obvious when BMSCs are cotransfected with miR-1260a mimics and pcDNA-NC, while matrix mineralization is significantly reduced when the BMSCs are cotransfected with miR-NC and pcDNA-HDAC7. b Quantitative analysis indicates overexpression of HDAC7 prevents the enhancement of osteoblast differentiation in BMSCs by miR-1260a mimics. c The scratch wound assay showing the areas of wound healing among different groups. d Quantitative analysis indicates overexpression of COL4A2 prevents the upregulation of the wound recovery rate of HUVECs by miR-1260a mimics. e The transwell assay showing the cell migration among different groups. f Quantitative analysis indicates overexpression of COL4A2 suppresses the upregulation of the migration rate of HUVECs by miR-1260a mimics. g Western blotting assays showing that overexpression of HDAC7 prevents the upregulation of OPN, Runx2, OCN, ALP and COL-1 protein expression by miR-1260a mimics. h Western blotting assays showing that overexpression of COL4A2 prevents the upregulation of VEGF, ANG-1 and HIF-1α protein expression by miR-1260a mimics