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. 2021 Jul 13;13:129. doi: 10.1186/s13195-021-00869-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Comparison of white matter hyperintensity volumes between groups. Box plots show white matter hyperintensity volumes on T2-weighted images according to neuropathological diagnosis, with lower and upper hinges of each boxplot corresponding to 25th and 75th percentiles of data. A SABRE parcellation of brain regions. B Total intracranial white matter hyperintensity burden. C Deep white matter and periventricular white matter hyperintensity burden. D Regional white matter hyperintensity volumetrics. Underneath the graphs are P values for differences between subgroups (ANOVA) and P’ values for differences between subgroups adjusting for age and vascular risk factors (ANCOVA). All bars in the figure are significant differences between each pair with * = P < 0.05 and ** = P < 0.005, corrected for age at imaging and vascular risk factors. Abbreviations: AD Alzheimer’s disease, CBD corticobasal degeneration, FTLD frontotemporal lobar degeneration, HC healthy controls, PSP progressive supranuclear palsy