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. 2021 Jul 13;13:129. doi: 10.1186/s13195-021-00869-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Selected examples of neuropathological findings in area of maximal white matter hyperintensity. A H&E/LFB staining of an FTLD-TDP case showing moderate (2) pallor of myelin staining within periventricular white matter (black arrow) in comparison to subcortical U fibers (green arrow); B H&E/LFB staining of an FTLD-tau (Pick’s) case showing pallor of periventricular myelin staining; C H&E/LFB staining of FTLD-tau (PSP) case showing severe myelin pallor; D H&E/LFB staining of an FTLD-tau (CBD) case showing collagenosis of large caliber periventricular veins; E GFAP immunolabeling of an FTLD-TDP case showing severe gliosis; F tau (AT8) immunohistochemistry of an FTLD-tau (CBD) case showing rare glial cytoplasmic tau immunopositive inclusions within the white matter region of interest (black arrow); G CD68 immunostaining of an FTLD-tau (Pick’s) case showing mild macrophage infiltration; H NF staining of an FTLD-tau (CBD) case showing severe axonal loss. Abbreviations: AD Alzheimer’s disease, CAA congophilic amyloid angiopathy, CBD corticobasal degeneration, CD68 cluster of differentiation 68, FTLD frontotemporal lobar degeneration, GFAP glial fibrillary acid protein, H&E/LFB Hematoxylin Eosin with Luxol Fast Blue, NF neurofilament, PSP progressive supranuclear palsy