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Dural IL-6 produces facial and hindpaw hypersensitivity in females. Female rats had baseline withdrawal thresholds established prior to receiving administration of 0.1 ng IL-6 onto the dura. Dural IL-6 (n = 10) elicited significant effect of treatment on facial (A) F (1, 66) = 31.58, p < 0.0001) and hindpaw (B) (F (1, 66) = 43.66, p < 0.0001) hypersensitivity when compared with animals that received vehicle (n = 4). *p < 0.05, ****p < 0.0001
