Table 3.
Univariable and multivariable adjustment for factors associated with POCD at 48 h after ablation in the study group
| Variable | Patients with POCD (n = 26) | Patients without POCD (n = 164) | Univariable adjustment | Multivariable adjustment | ||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |||
| Age (years) | 67.7 ± 6.3 | 66.4 ± 5.3 | 1.04 | 0.97–1.12 | 0.26 | – | – | – |
| Male | 12 (46.2) | 101 (61.6) | 1.87 | 0.81–4.30 | 0.14 | – | – | – |
| College and above | 5 (19.2) | 52 (31.7) | 0.51 | 0.18–1.44 | 0.20 | – | – | – |
| Paroxysmal atrial fibrillation | 17 (65.4) | 114 (69.5) | 1.21 | 0.50–2.89 | 0.67 | – | – | – |
| Diabetes | 3 (11.5) | 30 (18.3) | 0.58 | 0.16–2.07 | 0.40 | – | – | – |
| Hypertension | 16 (61.5) | 106 (64.6) | 0.88 | 0.37–2.05 | 0.76 | – | – | – |
| Dyslipidemia | 4 (15.4) | 37 (22.6) | 0.62 | 0.20–1.93 | 0.41 | – | – | – |
| Coronary artery disease | 6(23.1) | 24 (14.6) | 1.75 | 0.64–4.80 | 0.28 | – | – | – |
| Heart failure | 3 (11.5) | 7 (4.3) | 2.96 | 0.71–12.12 | 0.14 | – | – | – |
| Smoker | 4 (15.4) | 29 (17.7) | 0.85 | 0.27–2.64 | 0.77 | – | – | – |
| Oral antiplatelet drugs | 4 (15.4) | 15 (9.1) | 1.81 | 0.55–5.94 | 0.33 | – | – | – |
| ACEI/ARB | 10 (38.5) | 47 (28.7) | 1.56 | 0.66–3.68 | 0.31 | – | – | – |
| Statins | 13 (50.0) | 78 (47.6) | 1.10 | 0.48–2.52 | 0.82 | – | – | – |
| CHA2DS2-VASc score (< 2 for males, < 3 for females) | 11 (42.3) | 78 (47.6) | 0.81 | 0.35–1.87 | 0.62 | 0.95 | 0.38–2.39 | 0.91 |
| Level of depression | 2.6 ± 1.4 | 2.7 ± 1.2 | 0.93 | 0.66–1.30 | 0.67 | – | – | – |
| Level of anxiety | 3.7 ± 1.6 | 3.8 ± 1.3 | 0.97 | 0.70–1.34 | 0.85 | – | – | – |
| Intraoperative hypotension | 0 (0.0) | 2 (1.2) | 0.00 | 0.00 | 1.00 | – | – | – |
| Direct current cardioversion | 7 (26.9) | 34 (20.7) | 1.41 | 0.55–3.63 | 0.48 | – | – | – |
| Minimum intraoperative ACT < 300 s | 12 (46.2) | 38 (23.2) | 2.84 | 1.21–6.66 | 0.02* | 3.82 | 1.48–9.96 | 0.006* |
| Left atrial access time (min) | 125.6 ± 32.6 | 120.2 ± 38.1 | 1.00 | 0.99–1.01 | 0.50 | – | – | – |
| Radiofrequency duration (min) | 83.1 ± 31.0 | 80.0 ± 34.1 | 1.00 | 0.99–1.02 | 0.66 | – | – | – |
| Fentanyl dosage (μg) | 161.3 ± 45.3 | 160.5 ± 48.4 | 1.00 | 0.99–1.01 | 0.93 | – | – | – |
| Not on oral anticoagulant within 1-month prior to ablation | 21 (80.8) | 53 (32.3) | 8.80 | 3.14–24.6 | < 0.001* | 10.35 | 3.54–30.27 | < 0.001* |
| No oral anticoagulants interruption | 3 (11.5) | 24 (14.6) | 0.76 | 0.21–2.73 | 0.68 | – | – | – |
Values are presented as the mean ± SD or n (%)
OR, odds ratio; CI, confidence interval; the asterisk indicates statistical significance