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The mechanism of on-target off-tumor and killer inhibitory receptor (KIR) / PD-1-based inhibitory anti-CD19 CAR-T. a CAR-T cells can recognize and bind to targeted antigens (CD19) expressed on normal cells and cause on-target off-tumor toxicity; b The activation of CAR-T cells can be inhibited by PD-1 signal when KIR on CAR-T cells are engaged to HLA-C1 on normal cells, which can avoid the destruction of normal cells and on-target off-tumor toxicity of CAR-T cell therapy
