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. 2021 Jun 30;11:714756. doi: 10.3389/fonc.2021.714756

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Copyright © 2021 Wang, Liu, Li, Li, Li and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hepcidin downregulation is a worse survival factor in non-alcoholic liver cancer patients without viral hepatitis. (A, B) The survival status was analyzed on the Kaplan-Meier Plotter platform in patients with or without alcohol consumption. In panel A, the hepcidin expression range (RNA sequencing data) was 0-116709 and the cutoff value was 542. In panel B, the hepcidin expression range was 0-120133 and the cutoff value was 68 using the minimum p-value approach, as described (26). Case numbers in each group were listed at the bottom of the figure. (C, D) The survival status was analyzed in patients with or without viral hepatitis. The cutoff value for hepcidin expression was set as 440 (range 0-58791) in panel C and 168 in panel D (range 0-120133). (E, F) The survival status was analyzed in none-alcoholic patients with or without viral hepatitis. The cutoff value for hepcidin expression was 140 (range 0-49344) for the overall survival but 542 for the disease-free survival in (E). The cutoff value in D was 168 (range 0-116709).