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. 2021 Feb 25;24(6):519–531. doi: 10.1093/ijnp/pyab007

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© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Fluoroethylnormemantine (FENM) does not alter the startle response during pre-pulse inhibition. (a) Experimental protocol. (b) Memantine consistently reduced the startle response at multiple stimulus intensities compared with saline-administered rats. FENM (5, 10, or 20 mg/kg) did not alter the startle response. (c) Memantine, but not FENM, significantly reduced mean freezing compared with the saline control group (n = 12 male rats/group). Error bars represent ± SEM. **P < .01. Abbreviation: PPI, paired-pulse inhibition.