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Fluoroethylnormemantine (FENM) does not alter locomotion or exploratory behavior in the open field. (a) Experimental protocol. (b–d) Memantine, but not FENM, significantly reduced locomotion, rearing, and stereotypic behavior, respectively, in the open field (OF) compared with saline-administered rats. (e) Time in the center of the OF was comparable across all drug groups. (n = 12 male rats/group). Error bars represent ± SEM. ***P < .0001. Abbreviation: OF, open field.
