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. 2021 Feb 25;24(6):519–531. doi: 10.1093/ijnp/pyab007

Figure 5.

Figure 5.

Fluoroethylnormemantine (FENM) facilitates extinction learning. (a) Experimental protocol. (b–c) Freezing prior to the tones and during tones 1–8 was comparable between all the drug groups. FENM at 5 and 20, but not 10 mg/kg, significantly reduced freezing during tones 9–16 compared with saline-administered rats. (d) In tone test 2, FENM (20 mg/kg) significantly reduced overall freezing compared with the control saline group. (e) All doses of FENM significantly reduced freezing during tones 9–16. FENM (20 mg/kg) also reduced freezing during tones 17–24. (f) Experimental protocol. (g–h) During test 2, FENM (5 mg/kg) did not alter fear behavior compared with saline controls. FENM (10 mg/kg) reduced freezing during the pre-tone epoch and during tones 1–16. FENM (20 mg/kg) significantly reduced freezing throughout the entire testing session. (n = 7–9 male rats/group). Error bars represent ± SEM. *P < .05, **P < .01, ***P < .0001. Abbreviations: FC, fear conditioning; sal, saline.