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. 2021 Jun 30;9:682476. doi: 10.3389/fcell.2021.682476

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Copyright © 2021 Du, Li, Yan, Zeng, Han, Ouyang, Pan, Luo, Zhou, Fu, Lu, Huang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of the differentially expressed proteins from the MSCs in HLI vs. Sham at each time points. KEGG enrichment analyses of DEPs from the MSCs in HLI vs. in Sham hindlimb at days 1 (A), 3 (B), 7 (C), and 14 (D). KEGG pathway analysis of DEPs indicated a remarkable difference in cellular functions between HLI and Sham. Bubble graphs describe the distribution of DEPs in a classified KEGG pathway. The bubble size represents the differential protein expression level. The red bubbles show that the protein level in HLI is higher than that in Sham, whereas the green bubbles show the opposite trend.