Table 1.
Evolution of biological data
| At discharge(± 72 h) | Follow-upafter 1 month | Follow-upafter 3 months | |
|---|---|---|---|
| Days since hospital discharge, median (IQR) | 34 (28–46) | 93 (84–106) | |
| WBC (10³/mm³) | |||
| N | 178 | 57 | 71 |
| Median (IQR) | 6.0 (4.8–7.4) | 6.2 (5.3–7.8) | 6.9 (5.5–8.4) |
| n (%) out of rangea | 52 (29.2) | 9 (15.8) | 12 (16.9) |
| P-value evolutionb | 0.69 (n=53) | 0.57 (n=37) | |
| Haemoglobin (g/dL) | |||
| N | 176 | 55 | 71 |
| Median (IQR) | 12.3 (10.8–13.5) | 12.9 (11.9–14.0) | 13.9 (12.4–15.2) |
| n (%) <lower rangea | 66 (37.5) | 12 (21.8) | 11 (15.5) |
| P-value evolutionb | <0.0001 (n=50) | <0.0001 (n=35) | |
| Lymphocytes (%) | |||
| N | 176 | 55 | 71 |
| Median (IQR) | 24.5 (18.1–30.3) | 29.6 (24.8–37.3) | 31.4 (24.4–37.6) |
| n (%) out of rangea | 45 (25.6) | 9 (16.4) | 10 (14.1) |
| P-value evolutionb | <0.0001 (n=50) | 0.90 (n=35) | |
| Lymphocytes (10³/mm³) | |||
| N | 176 | 54 | 68 |
| Median (IQR) | 1.5 (1.1–1.8) | 1.5 (1.2–2.3) | 2.0 (1.7–2.5) |
| n (%) out of rangea | 42 (23.9) | 4 (7.4) | 4 (5.9) |
| P-value evolutionb | <0.0001 (n=49) | 0.86 (n=34) | |
| D-dimer (µg/L) | |||
| N | 75 | 46 | 72 |
| Median (IQR) | 841 (501–1534) | 446 (258–737) | 322 (190–599) |
| n (%) out of rangea | 57 (76.0) | 20 (43.5) | 24 (33.3) |
| P-value evolutionb | 0.0010 (n=16) | <0.0001 (n=28) | |
| TGO (ASAT) aspartate aminotransferase (U/L) | |||
| N | 168 | 54 | 72 |
| Median (IQR) | 35 (24–58) | 26 (22–31) | 26 (24–32) |
| n (%) out of rangea | 87 (51.8) | 10 (18.5) | 16 (22.2) |
| P-value evolutionb | 0.0078 (n=44) | 0.0030 (n=34) | |
| TGP (ALAT) alanine aminotransferase (U/L) | |||
| N | 167 | 55 | 72 |
| Median (IQR) | 47 (23–89) | 28 (17–45) | 26 (20–36) |
| n (%) out of rangea | 15 (9.0) | 0 (0.0) | 0 (0.0) |
| P-value evolutionb | 0.0002 (n=45) | 0.90 (n=34) | |
| Creatinine | |||
| N | 179 | 58 | 73 |
| Median (IQR) | 0.84 (0.70–1.0) | 0.83 (0.76–0.99) | 0.94 (0.77–1.1) |
| n (%) >upper rangea | 41 (22.9) | 12 (20.7) | 24 (32.9) |
| P-value evolutionb | 0.90 (n=54) | <0.0001 (n=38) | |
| GFR estimation (CKD-EPI) | |||
| N | 179 | 58 | 73 |
| Median (IQR) | 90.7 (76.8–101.2) | 90.7 (72.2–100.1) | 83.7 (63.2–93.1) |
| n (%) <60 | 26(14.5) | 8 (13.8) | 17 (23.3) |
| P-value evolutionb | 0.28 (n=38) | <0.0001 (n=38) | |
| Creatinine (without IRA patients) | |||
| N | 161 | 51 | 59 |
| Median (IQR) | 0.80 (0.70–0.95) | 0.83 (0.73–0.95) | 0.90 (0.74–1.0) |
| n (%) >upper rangea | 27 (16.8) | 8 (15.7) | 13 (22.0) |
| P-value evolutionb | 0.37 (n=48) | 0.0001 (n=31) | |
| GFR estimation (without IRA patients) | |||
| N | 161 | 51 | 59 |
| Median (IQR) | 92.8 (80.9–101.8) | 92.0 (74.1–101.6) | 86.5 (70.9–95.2) |
| n (%) <60 | 14 (8.7) | 5 (9.8) | 8 (13.6) |
| P-value evolutionb | 0.41 (n=48) | 0.0001 (n=31) | |
| Creatinine kinase (UI/L) | |||
| N | 94 | 59 | 61 |
| Median (IQR) | 58.5 (35.0–118) | 54.0 (22.0–99.0) | 112.0 (53.0–150.0) |
| n (%)>upper rangea | 13 (13.8) | 7 (11.9) | 11 (18.0) |
| P-value evolutionb | 0.66 (n=22) | <0.0001 (n=33) | |
| CRP (mg/L) | |||
| N | 180 | 53 | 70 |
| Median (IQR) | 20.4 (9.0–48.1) | 5.6 (1.3–6.7) | 2.7 (1.4–4.9) |
| n (%) >upper rangea | 158 (87.8) | 18 (34.0) | 17 (24.3) |
| P-value evolutionb | <0.0001 (n=49) | 0.28 (n=36) | |
| Ferritin (µg/L) | |||
| N | 31 | 50 | 63 |
| Median (IQR) | 671 (386–1012) | 179 (127–332) | 95 (46–171) |
| n (%) >upper rangea | 27 (87.1) | 21 (42.0) | 13 (20.6) |
| P-value evolutionb | - | <0.0001 (n=28) | |
IQR, interquartile range ; WBC, white blood cells ; GFR, glomerular filtration rate; CRP, C-reactive protein.
a
Reference ranges: WBC (10³/mm³): 4.6–10.1; haemoglobin (g/dL): 11.7–15.0; lymphocyte (%): 17.5–45.5; lymphocyte (10³/mm³): 1.1–3.7; D-dimer (µg/L): <500; TGO (ASAT) (U/L): 5–34, TGP (ALAT) (U/L): <150; creatinine (mg/dL): 0.55–1.02; GFR (MDRD) (mL/min/1.73 m²): <60; creatinine kinase (UI/L): 29–168; CRP (mg/L): 0.0–5.0; ferritin (µg/L): 5–204.
b
Signed rank test for paired observations, at discharge vs 1 month after discharge, or at 1 month after discharge vs 3 months after discharge (n=number of paired observations available).