Table 2.
The performance of different methods for distinguishing between ATB and LTBI.
| Methods | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| CD4+ T cell number (/μl) | 404 | 0.788† (0.694-0.882) | 57.41% (44.16%-69.67%) | 91.23% (81.06%-96.20%) | 86.11% (71.34%-93.92%) | 69.33% (58.17%-78.61%) | 6.54 (2.75-15.59) | 0.47 (0.34-0.64) | 74.77% |
| CD8+ T cell number (/μl) | 203 | 0.633‡ (0.528-0.737) | 35.19% (23.82%-48.52%) | 85.96% (74.68%-92.71%) | 70.37% (51.52%-84.15%) | 58.33% (47.65%-68.29%) | 2.51 (1.2-5.24) | 0.75 (0.6-0.94) | 61.26% |
| NK cell number (/μl) | 156 | 0.852* (0.778-0.927) | 68.52% (55.26%-79.32%) | 87.72% (76.75%-93.92%) | 84.09% (70.63%-92.07%) | 74.63% (63.07%-83.51%) | 5.58 (2.72-11.43) | 0.36 (0.24-0.54) | 78.38% |
| B cell number (/μl) | 93 | 0.629‡ (0.523-0.736) | 38.89% (27.04%-52.21%) | 85.96% (74.68%-92.71%) | 72.41% (54.28%-85.30%) | 59.76% (48.94%-69.70%) | 2.77 (1.34-5.72) | 0.71 (0.56-0.9) | 63.06% |
| HLA-DR+CD3+ T cells (%) | 24.7 | 0.611‡ (0.504-0.719) | 40.74% (28.68%-54.03%) | 80.70% (68.66%-88.87%) | 66.67% (49.61%-80.25%) | 58.97% (47.89%-69.22%) | 2.11 (1.13-3.93) | 0.73 (0.57-0.95) | 61.26% |
| Treg (%) | 3.82 | 0.613‡ (0.506-0.720) | 44.44% (32.00%-57.62%) | 80.70% (68.66%-88.87%) | 68.57% (52.02%-81.45%) | 60.53% (49.29%-70.75%) | 2.3 (1.25-4.23) | 0.69 (0.53-0.9) | 63.06% |
| CD4+ T cell function (%) | 13.8 | 0.766‡ (0.678-0.854) | 42.59% (30.33%-55.84%) | 92.98% (83.30%-97.24%) | 85.19% (67.52%-94.09%) | 63.10% (52.42%-72.63%) | 6.07 (2.25-16.41) | 0.62 (0.49-0.79) | 68.47% |
| CD8+ T cell function (%) | 41.2 | 0.782† (0.692-0.873) | 62.96% (49.63%-74.58%) | 92.98% (83.30%-97.24%) | 89.47% (75.87%-95.83%) | 72.60% (61.44%-81.51%) | 8.97 (3.41-23.59) | 0.4 (0.28-0.57) | 78.38% |
| NK cell function (%) | 62.1 | 0.744‡ (0.650-0.838) | 37.04% (25.42%-50.37%) | 91.23% (81.06%-96.20%) | 80.00% (60.87%-91.14%) | 60.47% (49.90%-70.14%) | 4.22 (1.71-10.45) | 0.69 (0.55-0.86) | 64.86% |
| Diagnostic model | 0.676 | 0.920 (0.867-0.973) | 81.48% (69.16%-89.62%) | 91.23% (81.06%-96.20%) | 89.80% (78.24%-95.56%) | 83.87% (72.79%-91.00%) | 9.29 (3.98-21.66) | 0.2 (0.12-0.36) | 86.49% |
*Compared with diagnostic model using z statistic, P < 0.05; †compared with diagnostic model using z statistic, P < 0.01; ‡compared with diagnostic model using z statistic, P < 0.001; ATB, active tuberculosis; LTBI, latent tuberculosis infection; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.