Table 3.
The performance of different methods for distinguishing between ATB and HC.
| Methods | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| CD4+ T cell number (/μl) | 404 | 0.768† (0.675-0.862) | 57.41% (44.16%-69.67%) | 85.00% (73.89%-91.90%) | 77.50% (62.50%-87.69%) | 68.92% (57.66%-78.31%) | 3.83 (2.01-7.29) | 0.5 (0.36-0.7) | 71.93% |
| CD8+ T cell number (/μl) | 203 | 0.661‡ (0.558-0.764) | 35.19% (23.82%-48.52%) | 90.00% (79.85%-95.34%) | 76.00% (56.57%-88.51%) | 60.67% (50.29%-70.18%) | 3.52 (1.52-8.16) | 0.72 (0.58-0.89) | 64.04% |
| NK cell number (/μl) | 156 | 0.877 (0.809-0.945) | 68.52% (55.26%-79.32%) | 95.00% (86.30%-98.29%) | 92.50% (80.14%-97.42%) | 77.03% (66.25%-85.13%) | 13.7 (4.48-41.9) | 0.33 (0.22-0.49) | 82.46% |
| B cell number (/μl) | 93 | 0.632‡ (0.525-0.738) | 38.89% (27.04%-52.21%) | 85.00% (73.89%-91.90%) | 70.00% (52.12%-83.34%) | 60.71% (50.02%-70.47%) | 2.59 (1.3-5.16) | 0.72 (0.57-0.91) | 63.16% |
| HLA-DR+CD3+ T cells (%) | 24.7 | 0.625‡ (0.517-0.733) | 40.74% (28.68%-54.03%) | 85.00% (73.89%-91.90%) | 70.97% (53.41%-83.91%) | 61.45% (50.69%-71.19%) | 2.72 (1.37-5.38) | 0.7 (0.55-0.89) | 64.04% |
| Treg (%) | 3.82 | 0.653‡ (0.548-0.758) | 44.44% (32.00%-57.62%) | 90.00% (79.85%-95.34%) | 80.00% (62.70%-90.50%) | 64.29% (53.62%-73.70%) | 4.44 (1.97-10.05) | 0.62 (0.48-0.8) | 68.42% |
| CD4+ T cell function (%) | 13.8 | 0.764‡ (0.676-0.852) | 42.59% (30.33%-55.84%) | 90.00% (79.85%-95.34%) | 79.31% (61.61%-90.16%) | 63.53% (52.92%-72.97%) | 4.26 (1.88-9.67) | 0.64 (0.5-0.81) | 67.54% |
| CD8+ T cell function (%) | 41.2 | 0.761‡ (0.669-0.852) | 62.96% (49.63%-74.58%) | 83.33% (71.97%-90.69%) | 77.27% (63.01%-87.16%) | 71.43% (59.95%-80.68%) | 3.78 (2.07-6.89) | 0.44 (0.31-0.64) | 73.68% |
| NK cell function (%) | 62.1 | 0.716‡ (0.620-0.813) | 37.04% (25.42%-50.37%) | 93.33% (84.08%-97.38%) | 83.33% (64.15%-93.32%) | 62.22% (51.90%-71.54%) | 5.56 (2.03-15.23) | 0.67 (0.54-0.84) | 66.67% |
| Diagnostic model | 0.676 | 0.911 (0.855-0.967) | 81.48% (69.16%-89.62%) | 90.00% (79.85%-95.34%) | 88.00% (76.20%-94.38%) | 84.38% (73.57%-91.29%) | 8.15 (3.77-17.59) | 0.21 (0.12-0.36) | 85.96% |
†Compared with diagnostic model using z statistic, P < 0.01; ‡compared with diagnostic model using z statistic, P < 0.001; ATB, active tuberculosis; HC, healthy controls; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.