Table 2.

Managing patients with suspected or confirmed vaccine induced thrombotic thrombocytopaenia (VITT)

Dos	Don’ts
Laboratory testing by PF4 antibody assay (ELISA HIT assay)	Do not exclude VITT based on a negative HIT screen from a rapid particle gel immunoassay
Commence therapeutic anticoagulation with non-heparin-based therapies	Avoid heparin, including heparin-based flushes. Fondaparinux can be used
Urgently treat with IVIG	Avoid platelet transfusion
Consider giving corticosteroids	Avoid thrombopoietin receptor agonists
Report to regulatory health agencies	Do not give a second dose of any vaccine for SARS-CoV-2 until further data are available

HIT, heparin-induced thrombocytopaenia; IVIG, intravenous immunoglobulin; PF4, platelet factor 4.