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. 2021 Jun 22;12(27):9475–9484. doi: 10.1039/d1sc03007h

Coupling of amino-C11-hexylamidoDNA 3 with a diverse set of acids. Conditions: 3 (5 nmol), acid (0.5 M), 2,6-lutidine (2 M), HATU (0.5 M), 3.5% TPGS, 30 μl total volume, 45 °C, 16 h.

Acids % Conversion % Product
1 graphic file with name d1sc03007h-u2.jpg 100 100
2 graphic file with name d1sc03007h-u3.jpg 100 98
3 graphic file with name d1sc03007h-u4.jpg 97 94
4 graphic file with name d1sc03007h-u5.jpg 93 93
5 graphic file with name d1sc03007h-u6.jpg 100 100
6 graphic file with name d1sc03007h-u7.jpg 100 98
7 graphic file with name d1sc03007h-u8.jpg 100 97
8 graphic file with name d1sc03007h-u9.jpg 100 98
9 graphic file with name d1sc03007h-u10.jpg 100 97
10 graphic file with name d1sc03007h-u11.jpg 100 98
11 graphic file with name d1sc03007h-u12.jpg 100 89
12 graphic file with name d1sc03007h-u13.jpg 100 100
13 graphic file with name d1sc03007h-u14.jpg 94 94
14 graphic file with name d1sc03007h-u15.jpg 100 95
15 graphic file with name d1sc03007h-u16.jpg 100 100