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. 2021 Jun 9;12(27):9386–9390. doi: 10.1039/d1sc01378e

Synthesis of Fmoc-protected Q4As via imidazolidinones 3.

R= X= 3, yield (S)-4, yield/% (scale)
H 4-Br 3a, 94 4a, 83 (1.8 g)
H 3-Br 3b, 91 4b, 50 (1.5 g)
H 3-CN 3c, 83
H 3,5-F2 3d, 91 4d, 67 (0.5 g)
H 3,5-Cl2 3e, 90
Ph 4-Cl 3f, 89 4f, 51 (0.2 g)
Ph 4-Me 3g, 80 4g, 62 (0.4 g)
Ph 3-Br 3h, 95 4h, 50 (0.4 g)
4-BnOC6H4 4-Me 3i, 88
4-BnOC6H4 3-F, 4-Br 3j, 93