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Simplified mechanistic knowledge captured in AOPs speeds up development of relevant in vitro DNT assays to be further incorporated in the existing DNT-IVB and insures coverage of key DNT mechanisms. Schematic representation of impaired key neurodevelopmental processes defined as key events (KEs) in DNT AOPs (hiPSCs: human induced pluripotent stem cells; NPCs: Neural Precursor cells; MIE: Molecular Initiating Event; AO: Adverse Outcome).
