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. Author manuscript; available in PMC: 2021 Jul 14.
Published in final edited form as: Glia. 2019 Oct 18;68(3):495–508. doi: 10.1002/glia.23731

FIGURE 2.

FIGURE 2

Global loss of FMRP leads to reduced myelin sheath length. Lateral images of oligodendrocytes in the spinal cord of living wild-type (a) and mzfmr1−/− (b) larvae labeled by mbp:EGFP-CAAX. The mbp:EGFP-CAAX reporter distinctly labels individual myelin sheaths (brackets). Average sheath length (c), sheaths per cell (d), and total cumulative sheath length (e) in wild-type and mzfmr1−/− loss-of-function mutants. Violin plot centerlines represent median values and hinges represent 25th and 75th percentiles, with all data points shown. Wild-type: n = 234 sheaths, 27 cells; mzfmr1−/−: n = 247 sheaths, 24 cells. Significance determined by Mann–Whitney tests. Scale bar = 10 μm