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. Author manuscript; available in PMC: 2021 Jul 14.
Published in final edited form as: Glia. 2019 Oct 18;68(3):495–508. doi: 10.1002/glia.23731

FIGURE 3.

FIGURE 3

Fragile X mental retardation protein (FMRP) promotes dynamic myelin sheath growth. sox10: mRFP+ myelin sheaths in the dorsal spinal cord of transgenic Tg(sox10:mRFP) wild-type (a) and fmr1−/− mutant (b) larvae at 3 dpf. Lateral three-dimensional images of the spinal cord were captured every 15 min for 4 hr (each row represents an hourly time point; scale bar = 10 μm). (a′,b′) High magnification detail of individual sox10:mRFP+ myelin sheaths, inset in (a) and (b) (scale bar = 5 μm). Numbers in top right corners denote time elapsed from initial time point. (c) Change in average length of individual myelin sheaths (t240 − t0; wild-type = 35 sheaths, eight larvae; fmr1−/− = 35 sheaths, seven larvae; Mann–Whitney test). Positive values indicate sheath growth and negative values denote retraction from the initial time point. (d) Dynamic range of individual myelin sheaths (maximum value − minimum value; unpaired t test) [Color figure can be viewed at wileyonlinelibrary.com]