Table 3.

Cox regression analysis examining the association between the composite index of slowing and 15-month incidence of new onset syndromal depression/anxiety

							95.0% CI for Exp(B)
Variables	B	SE	Wald	df	Sig.	Exp(B)	Lower	Upper
Covariates
Age	0.004	0.016	0.064	1	0.801	1.004	0.972	1.037
Depression symptoms	0.078	0.055	2.027	1	0.154	1.081	0.971	1.203
Anxiety symptoms	0.115	0.052	4.877	1	0.027	1.122	1.013	1.242
Treatment group	0.103	0.288	0.127	1	0.721	1.108	0.630	1.951
Measures of slowing			6.872	3	0.076
No slowing in either domain	(ref)
Gait slowing	0.631	0.325	3.765	1	0.052	1.880	0.994	3.555
Psychomotor slowing	−0.519	0.749	0.480	1	0.488	0.595	0.137	2.583
Composite index of slowing	0.748	0.374	3.998	1	0.046	2.113	1.015	4.397

Notes. There were no differences across the three RCTs on new-onset depression/anxiety:

Mild cognitive impairment*: B=0.10, SE = 0.34, Exp (B) = 1.106, 95% CI – 0.56 – 2.15, p=0.76.

Knee OA*: B=0.73, SE = 0.38, Exp (B) = 2.079, 95% CI – 0.973 – 4.443, p=0.06.

^*disabilities requiring home care served as the referent category. These p-values were not adjusted for multiple comparisons, given that even with no adjustment, they did not reach traditional levels for statistically reliable effects.