Table 5.

Hyaluronidase Safety Aspects

Incidence	Local reactions	0.05–0.69%
	Urticaria, angioedema	< 0.1%
	Anaphylaxis	Rare
Relative C/I	Wasp/bee sting allergy
Drug interactions	Furosemide, benzodiazepines, a-adrenergics, phenytoin
Antagonists	NSAID’s, antihistamines, Vit C, AOX’s, aspirins
Pre-Rx	Infective/Inflammatory nodules	Consider antibiotics 2-7-days Steroids
Intradermal test*	4–20 IU intradermal forearm Positive: > 8mm wheal + flare at 30 min Test not indicated if retinal artery occlusion/intravascular emergency
Post-Rx observation	1–2 Hours observation in - clinic recommended

Note: *Not indicated in the event of intravascular or ophthalmic events. Data from Cavallini et al.⁸⁸