. 2021 Jul 6;14:779–814. doi: 10.2147/CCID.S315711

Table 6.

Hyaluronidase Practical Aspects

Consent	Mandatory informed consent: aesthetic use may be off-label; check country-specific recommendations
Diluent	Saline, bacteriostatic saline, water
Dilution	Eg 1–10 mL/1500 IU
Timing	Onset of action	Immediate
	T ½	2 minutes
	Duration of action	48 hours
	Recovery time endogenous HA	48 hours
	Serum half-life	2 ½ minutes
Dosage	Nodules	4–40 IU/0.1 mL HA
	Vascular events	HDPH: 500 −1500 IU hourly
	Endogenous HA degradation	Higher than standard treatment doses
Technical aspects	Massage to increase contact Consider cannula to minimize eventual bruising

Note: Data from King et al⁸⁹ and Rauso et al.⁹⁰^,⁹¹

Abbreviation: HDPH, high dose pulse hyaluronidase.