Table 1. Biological Evaluation of Pyrimidines Derivatives on the Enzymatic Activity of Aurora A and Levels of MYC in MYC-Amplified Cancer Cells.

^aValues are the mean of 2–3 independent determinations ± SD (standard deviation).

^bInhibition < 50% at 100 nM.

^cRelative protein level (mean ± SD) of cMYC in NCI-H82 and MYCN in SK-N-BE(2) under 1.0 μM of compound treatment. Experiments were undertaken in triplicate.