Table 2. Enzymatic Inhibitor Activity of Compounds 6–17 and Relative LogD^7.4, Solubility, and Protein Binding^a.

compd	hDHODH, IC50  ± SE (nM)	LogD7.4  ± SDc	solubility (μM) in PBS	protein binding (% bond)
6	90.9 ± 13.1	0.66 ± 0.08	438	nd
7	1.35 ± 0.45	nd	nd	nd
8	6.23 ± 0.63	0.98 ± 0.03	47.3	99.58
9	150 ± 15	1.84 ± 0.06	20.2	nd
10	17.7 ± 3.30	insoluble	<LOD	nd
11	2.03 ± 0.44	2.09 ± 0.04	<LOD	99.96
12	71.8 ± 9.42	insoluble	<LOD	nd
13	6.34 ± 0.63	2.69 ± 0.03	<LOD	99.94
14	2.78 ± 0.32	1.82 ± 0.09	55.3	nd
15	2.30 ± 0.33	3.27 ± 0.19	8.1	100
16	2.75 ± 0.31	2.46 ± 0.04	74.3	99.95
17	4.09 ± 0.62	3.28 ± 0.12	12.9	100

^aThe effect of the compounds is expressed as IC₅₀ values. Limit of detection (LOD): 6 μM. The “nd” notation indicates that the compound was not tested in that specific assay.