Figure 5.

Effects of MDP and desmuramylpeptides on the cytotoxic activities of PBMCs against K562 and MEC1 cells. (A) PBMCs were treated for 18 h with MDP (10 μM), desmuramylpeptides (10 μM), or LPS (1 μg/mL) before the addition of the K562 or MEC1 cells. Cytotoxicity was determined after 4 h co-incubation. (B) Concentration-dependent effect of 75 on the induction of PBMC cytotoxicity. Data are shown as activities relative to the negative control (NT, 0.1% DMSO) and are expressed as mean ± SEM of three (MEC1) or four (K562) independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 versus relevant negative controls.