Scheme 4. Synthesis of Compounds 56–64.
Reagents and conditions: (i) trans-ferulic acid, EDC, HOBt, DIPEA, DMAP, DMF, rt; (ii) 1 M NaOH, EtOH, rt; (iii) 44, EDC, HOBt, DIPEA, DMAP, DMF, rt; (v) 47–55, EDC, HOBt, DIPEA, DMAP, DMF, rt.
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