Table 3. NOD2 Agonistic Activities of the Lipophilic Desmuramylpeptides.

^aSEAP activities were measured in NOD2-specific HEK-Blue cell supernatants after incubation for 18 h with MDP (2 μM) or the compounds of interest (2 μM). The data are shown as fold increases of NF-κB transcriptional activity relative to the negative control (0.1% DMSO) and are expressed as mean ± SEM of at least two independent experiments.

^bEC₅₀ values are expressed as mean ± SEM of at least two independent experiments with 7 or 8 concentrations used (from 1 nM to 20 μM). ND, not determined.

^cClogP values as calculated by the ChemDraw software.