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3D pharmacophore models for σ2R: (A) Pharmacophore mapping of compound C in 3D models derived by Vio et al. (B) Pharmacophore mapping of compound D in 3D models derived by Iyamu et al. Color coded as follows: PI (red), HYAr or HYD (light blue), HY (pink), HBA (light green), excluded volumes (gray).
