. 2021 Jun 2;64(12):7926–7962. doi: 10.1021/acs.jmedchem.0c02265

Table 2. σ₁R Binding Profile of Compounds 38–43 and ent-38–43.

Compd.	σ₁K_i [nM]^a (guinea pig brain)	σ₂K_i [nM]^a (rat liver)	σ₁K_i [nM]^a (human RPMI 8226 cell line)
38	4.8	36	3.2
ent-38	23	197	2.8
39	6.9	60	2.4
ent-39	5.7	501	1.6
40	8.0	51	13
ent-40	14	40	38
41	7.1	157	7.2
ent-41	0.50	116	6.0
42	8.7	20	27
ent-42	11	202	27
43	23	334	73
ent-43	11	593	24

Data from ref (132).

Table 2. σ1R Binding Profile of Compounds 38–43 and ent-38–43.