Table 2:
Relationship between immune infiltrate and morphologic subtype.
| CIBERSORT | |||
|---|---|---|---|
| FOLLICULAR VARIANT PTC | |||
| Cell Type | OR | 95% CI | p value |
| Naïve B cells | 0.95 | 0.90–1.0 | 0.038 |
| Memory B cells | 0.93 | 0.82–1.1 | 0.26 |
| Plasma cells | 0.97 | 0.92–1.0 | 0.38 |
| CD8 T cells | 1.0 | 0.97–1.1 | 0.71 |
| Resting CD4 memory T cells | 0.97 | 0.93–1.0 | 0.24 |
| Activated CD4 memory T cells | 0.65 | 0.41–1.0 | 0.068 |
| Follicular helper T cells | 1.1 | 0.97–1.1 | 0.25 |
| Regulatory T cells | 0.96 | 0.87–1.1 | 0.40 |
| Gamma delta T cells | 0.96 | 0.86–1.1 | 0.45 |
| M0 macrophages | 0.93 | 0.89–0.96 | 1.3 × 10−5 |
| M1 macrophages | 0.91 | 0.83–0.99 | 0.023 |
| M2 macrophages | 1.0 | 0.96–1.0 | 1.0 |
| Resting dendritic cells | 0.90 | 0.85–0.95 | 3.1 × 10−4 |
| Activated dendritic cells | 0.86 | 0.76–0.97 | 0.014 |
| Neutrophils | 0.53 | 0.22–1.3 | 0.16 |
| TALL CELL VARIANT PTC | |||
| Cell Type | OR | 95% CI | p value |
| Naïve B cells | 1.0 | 0.97–1.1 | 0.27 |
| Memory B cells | 0.90 | 0.72–1.1 | 0.36 |
| Plasma cells | 1.0 | 0.93–1.1 | 0.71 |
| CD8 T cells | 0.93 | 0.85–1.0 | 0.12 |
| Resting CD4 memory T cells | 1.0 | 0.92–1.1 | 0.97 |
| Activated CD4 memory T cells | 1.2 | 0.83–1.7 | 0.36 |
| Follicular helper T cells | 0.98 | 0.86–1.1 | 0.70 |
| Regulatory T cells | 1.1 | 1.0–1.3 | 0.071 |
| Gamma delta T cells | 0.85 | 0.65–1.1 | 0.25 |
| M0 macrophages | 1.0 | 0.95–1.1 | 0.80 |
| M1 macrophages | 1.1 | 0.91–1.2 | 0.50 |
| M2 macrophages | 0.94 | 0.87–1.0 | 0.16 |
| Resting dendritic cells | 1.1 | 1.0–1.2 | 0.042 |
| Activated dendritic cells | 0.97 | 0.82–1.1 | 0.72 |
| Neutrophils | 1.9 | 0.86–4.0 | 0.12 |
| TIMER | |||
| FOLLICULAR VARIANT PTC | |||
| Cell Type | OR | 95% CI | p value |
| DCs | 0.057 | 0.019–0.18 | 5.1 × 10−7 |
| CD8 T cells | 0.22 | 0.080–0.61 | 3.4 × 10−3 |
| CD4 T cells | 0.14 | 6.6 × 10−3-3.1 | 0.21 |
| Macrophages | 0.58 | 0.13–2.6 | 0.48 |
| B cells | 0.34 | 0.11–1.1 | 0.063 |
| Neutrophils | 1.3 ×10−3 | 5.3 × 10−5-0.031 | 4.1 × 10−5 |
| TALL CELL VARIANT PTC | |||
| Cell Type | OR | 95% CI | p value |
| DCs | 4.5 | 1.6–13 | 4.9 × 10−3 |
| CD8 T cells | 0.50 | 0.13–1.9 | 0.32 |
| CD4 T cells | 0.15 | 1.8 × 10−3-12 | 0.40 |
| Macrophages | 0.60 | 0.020–18 | 0.77 |
| B cells | 1.1 | 0.19–5.9 | 0.94 |
| Neutrophils | 4.5 | 0.51–39 | 0.18 |