Table 3:

Relationship between immune infiltrate and mutational status.

CIBERSORT
BRAF MUTATION
Cell Type	OR	95% CI	p value
Naïve B cells	1.1	1.1–1.2	5.2 × 10−5
Memory B cells	0.98	0.89–1.1	0.73
Plasma cells	1.0	1.0–1.1	0.13
CD8 T cells	0.98	0.94–1.0	0.21
Resting CD4 memory T cells	1.0	0.99–1.1	0.13
Activated CD4 memory T cells	1.3	0.95–1.7	0.13
Follicular helper T cells	0.92	0.86–0.98	0.014
Regulatory T cells	1.1	1.0–1.2	3.8 × 10−3
Gamma delta T cells	1.0	0.93–1.1	0.64
M0 macrophages	1.1	1.0–1.1	3.9 × 10−4
M1 macrophages	1.1	1.1–1.2	7.5 × 10−4
M2 macrophages	1.0	0.99–1.1	0.20
Resting dendritic cells	1.1	1.1–1.1	3.8 × 10−5
Activated dendritic cells	1.2	1.1–1.3	7.8 × 10−4
Neutrophils	0.76	0.39–1.3	0.39
RAS MUTATION
Cell Type	OR	95% CI	p value
Naïve B cells	0.89	0.80–0.98	0.028
Memory B cells	0.92	0.76–1.1	0.39
Plasma cells	0.95	0.85–1.1	0.38
CD8 T cells	1.1	1.0–1.1	3.9 × 10−3
Resting CD4 memory T cells	1.1	0.99–1.1	0.10
Activated CD4 memory T cells	0.33	0.044–0.88	0.13
Follicular helper T cells	1.13	1.0–1.3	0.027
Regulatory T cells	1.1	0.96–1.2	0.20
Gamma delta T cells	1.1	0.96–1.2	0.15
M0 macrophages	1.0	0.98–1.1	0.55
M1 macrophages	0.87	0.76–0.98	0.023
M2 macrophages	1.1	1.02–1.1	6.9 × 10−3
Resting dendritic cells	0.92	0.83–0.99	0.045
Activated dendritic cells	0.84	0.71–0.96	0.023
Neutrophils	0.98	0.50–1.8	0.94
TIMER
BRAF MUTATION
Cell Type	OR	95% CI	p value
DCs	42	19–101	2.0 × 10−16
CD8 T cells	7.3	3.4–17	1.1 × 10−6
CD4 T cells	0.70	0.072–6.7	0.76
Macrophages	12	3.0–52	6.1 × 10−4
B cells	3.1	1.1–9.0	0.038
Neutrophils	32	6.2–181	5.6 × 10−5
RAS MUTATION
Cell Type	OR	95% CI	p value
DCs	8.0 × 10−3	7.0 × 10−4-0.051	1.0 × 10−5
CD8 T cells	0.040	5.1 × 10−3-0.22	6.2 × 10−4
CD4 T cells	1.3 × 10−3	3.0 × 10−6-0.22	0.019
Macrophages	0.50	0.084–2.6	0.39
B cells	7.14 × 10−6	5.7 × 10−10-5.6 × 10−3	3.2 × 10−3
Neutrophils	1.3 × 10−3	6.0 × 10−6-0.094	7.0 × 10−3