Table 2.
Univariable and Multivariable Regression For Predictors of Recurrence in the UHN Cohort
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Sex (ref., male) | 0.62 (0.39‐0.99) | 0.05 | ‐ | ‐ |
| Age (per year) | 1.03 (1.00‐1.05) | 0.01 | 1.03 (1.01‐1.05) | 0.01 |
| Etiology (ref., HCV) | ||||
| HBV | 0.43 (0.25‐0.72) | 0.001 | ‐ | ‐ |
| Alcohol | 0.64 (0.19‐2.11) | 0.46 | ‐ | ‐ |
| NASH | 1.46 (0.60‐3.54) | 0.40 | ‐ | ‐ |
| Other | 1.09 (0.42‐2.84) | 0.85 | ‐ | ‐ |
| None | 0.99 (0.55‐1.77) | 0.97 | ‐ | ‐ |
| BMI (per kg/m2) | 1.00 (0.99‐1.01) | 0.69 | ‐ | |
| MELD (per point) | 1.03 (0.91‐1.17) | 0.61 | ‐ | |
| Serum AFP (ref., <20 ng/mL) | ||||
| 20‐100 ng/mL | 1.05 (0.54‐2.02) | 0.89 | ‐ | ‐ |
| 100‐1,000 ng/mL | 0.85 (0.50‐1.49) | 0.57 | ‐ | ‐ |
| >1,000 ng/mL | 0.99 (0.53‐1.87) | 0.99 | ‐ | ‐ |
| Specimen tumor size, cm | 1.08 (1.04‐1.14) | <0.001 | ‐ | ‐ |
| Specimen tumor number | 1.11 (1.03‐1.20) | 0.01 | 1.10 (1.07‐2.67) | 0.01 |
| DUSP9 level (ref., low) | 1.53 (1.01‐2.43) | 0.05 | 1.55 (1.01‐2.37) | 0.05 |
| R0 status (ref., yes) | 0.91 (0.37‐2.25) | 0.84 | ‐ | ‐ |
| Microvascular invasion (ref., no) | 2.16 (1.39‐3.35) | 0.01 | 1.69 (1.07‐2.67) | 0.02 |
| Macrovascular invasion (ref., no) | 5.69 (3.01‐10.75) | <0.001 | 5.05 (2.59‐9.85) | <0.001 |
| Tumoral differentiation (ref., well) | ||||
| Moderate | 2.35 (0.58‐9.57) | 0.23 | ‐ | ‐ |
| Poorly | 1.66 (0.36‐7.57) | 0.51 | ‐ | ‐ |
Abbreviations: BMI, body mass index; HBV, chronic hepatitis B; HCV, chronic hepatitis C; MELD, Model for End‐Stage Liver Disease; NASH, nonalcoholic steatohepatitis; R0, negative resection margin.