Figure 2.

Rational design of QNX derivatives and subgrouping criteria. Strategies adopted to modify the structure of the native LXA₄ compound (top-right corner) to obtain eight derivatives. QNX-sLXms contain an ortho-disubstituted quinoxaline ring (top-left corner). Modifications to the “upper chain” are highlighted in orange, while modifications to the “lower chain” are highlighted in green: based on this classification, the screening has been carried out on four subgroups of candidates [A (precursor), B, C, and D].