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. 2021 Jun 17;64(13):9193–9216. doi: 10.1021/acs.jmedchem.1c00403

Figure 7.

Figure 7

Effect of (R)-6 on TNF-α-induced NF-κB-driven luciferase activity in vSMCs. Mouse primary vSMCs transfected with an NF-κB reporter plasmid (pNF-κB-SEAP vector) were pretreated for 30 min with sLXm (R)-6 (1 nM), vehicle, or appropriate controls. After 24 h from subsequent stimulation with TNF-α (1 ng/mL), supernatants were collected and NF-κB-driven luciferase was assayed. Data are expressed as fold change relative to vehicle ± SEM (n = 6–8). Statistical analyses using Student’s unpaired two-tailed t-test of the tested compound vs TNF-α (**p < 0.01; ****p < 0.0001).