Figure 8.

Effects of (R)-6 on E. coli-derived bioparticle phagocytosis by THP-1-MF0 macrophage. A total of 1 × 10⁵ THP-1-MF0 macrophage were pretreated for 30 min with sLXms or appropriate controls (1 fM–1 μM), following incubation (for 2 h at 37 °C) with fluorescently labeled E. coli-derived bioparticles, prior to measuring the fluorescent signal indicating the uptake of the bioparticles by the macrophages. Data are expressed as fold change ± SEM (n = 3). Concentration–response curves show the E_max (black circles) and EC₅₀ (white circles). Statistical analyses were carried out using Student’s unpaired two-tailed t-test of the tested compound vs vehicle-treated (veh) (not shown).