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(i) A child is exposed to or infected with SARS-CoV-2. (ii) SARS-CoV-2 enters the GI tract. (iii) Dysbiosis leads to increased zonulin release and a resultant loss of tight junctions. (iv) SARS-CoV-2 antigens, especially the spike protein, breaches the mucosal barrier and enters the blood stream. (v) The superantigen motif of the spike protein stimulates a pathogenic hyperinflammatory response.
