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. 2021 Jul 15;131(14):e147025. doi: 10.1172/JCI147025

Figure 1. FOXA1 levels inversely correlate with IFN signaling gene expression in prostate (PCa) and breast cancer (BCa).

Figure 1

(A) GSEA enrichment plots show the inverse correlation between FOXA1 expression and IFN response hallmark genes in PCa and BCa from TCGA database. The FOXA1-high and -low groups were defined using the median as the cutoff. (B and C) Heatmaps show the inverse correlation of FOXA1 expression with IFN response signature genes and APM genes in single-cell RNA-seq data of PCa (B) and BCa (C) samples. Statistical significance was determined by Pearson’s correlation test.