TABLE 1.
Anthropometric and metabolic parameters
| Treatment | wild‐type | wild‐type | DDOST+/−Pod−Cre | DDOST+/−Pod−Cre | Two‐way ANOVA | |||
|---|---|---|---|---|---|---|---|---|
| (STZ induction) | non‐diabetic | diabetic | non‐diabetic | diabetic | G | D | G•D | |
| Body weight (g) | 12 weeks | 32.82 ± 3.12 | 27.14 ± 2.48 | 32.00 ± 4.62 | 26.56 ± 4.16 | 0.93 | 0.0001 | 0.59 |
| Kidney weight (g × body weight 103) | 12 weeks | 11.62 ± 1.44 | 14.74 ± 2.27 | 11.03 ± 1.21 | 15.93 ± 3.91 | 0.74 | 0.0001 | 0.33 |
| Food consumption (g/24 h) | 2 weeks | 3.26 ± 0.80 | 3.62 ± 0.49 | 3.63 ± 1.12 | 2.70 ± 1.01 | 0.46 | 0.44 | 0.086 |
| 12 weeks | 2.68 ± 0.58 | 4.79 ± 1.13 | 2.50 ± 0.95 | 4.13 ± 1.55 | 0.28 | <0.0001 | 0.55 | |
| Water consumption (ml/24 h) | 2 weeks | 5.22 ± 2.91 | 5.70 ± 2.91 | 4.74 ± 1.24 | 3.24 ± 1.49 | 0.12 | 0.58 | 0.29 |
| 12 weeks | 4.97 ± 8.49 | 17.70 ± 9.77 | 2.94 ± 1.80 | 14.06 ± 10.28 | 0.35 | 0.0004 | 0.79 | |
| Urine production (ml/24 h) | 2 weeks | 0.52 ± 0.34 | 1.19 ± 0.69 | 1.34 ± 0.83 | 0.78 ± 0.91 | 0.40 | 0.72 | 0.081 |
| 12 weeks | 1.20 ± 0.76 | 15.83 ± 8.05 | 2.03 ± 1.77 | 12.53 ± 10.84 | 0.60 | <0.0001 | 0.39 | |
| Fasting blood glucose (mmol/L) | 12 weeks | 9.22 ± 2.72 | 23.53 ± 3.80 | 10.10 ± 2.95 | 19.66 ± 6.94 | 0.35 | <0.0001 | 0.14 |
| GHb (mmol/mol) | 12 weeks | 4.22 ± 1.68 | 7.72 ± 3.79 | 3.35 ± 0.28 | 6.86 ± 3.83 | 0.45 | 0.0048 | 0.99 |
Values are mean ± SD (n = 5–11).
Abbreviations: D, diabetes; G D, interaction; G, genotype; GHb, glycated haemoglobin; STZ, streptozotocin.
Bold values indicate a significant (P < 0.05) effect.