FIGURE 3.

Proposed link between renal GLP‐1R activation and renin recruitment. Expression of Ren1 after GLP‐1RA exposure may be initiated by two mechanisms, both starting with GLP‐1R activation in renal arteries: (1) Activation leads to increased angiotensin II cleavage, which in turn leads to renin recruitment by lack of negative feedback mechanism. The product of the cleavage of angiotensin II, angiotensin 1‐7, activates the Mas1 receptor resulting in anti‐inflammatory and antifibrotic effects. (2) Activation leads to an increase in cAMP levels resulting in increased expression of Ren1 in the VSMC of the arteries. This would lead to an increase in local RAAS components including angiotensin II, which when cleaved as proposed above would further contribute to increased angiotensin 1‐7 levels