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. Author manuscript; available in PMC: 2021 Jul 14.
Published in final edited form as: J Leukoc Biol. 2019 Mar 12;105(5):1027–1039. doi: 10.1002/JLB.3A0918-345RR

FIGURE 5. Cell subpopulations in CNS at day 18.

FIGURE 5

Leukocytes were evaluated in the CNS at day 18 after MOG immunization. (A) Total number of leukocytes shows a significant decrease in Cxcl17−/− mice compared to WT littermates. From the myeloid subpopulation evaluated, a significant reduction in CD11b+ cells and F4/80+ MHC-II+ was observed. (B) Except for the CD8+ IFN-γ+ subpopulation, similar numbers of pathogenic and regulatory FoxP3+ T cells were present in the CNS at day 18 following EAE induction. Student’s t-test was performed to determine significance. All values are means ± SEM. Asterisks indicate significant differences (*P < 0.1, **P < 0.01, ***P < 0.001). Data are representative from 2 or more individual experiments, using a minimum of 6 to 10 animal per group