TABLE 1.

Proinflammatory panel during EAE

		WT		Cxcl17−/−
Inflammatory panel	Days after EAE	Mean (pg/mL)	SEM	Mean (pg/mL)	SEM	SS
IL-23	Control	7.27	1.73	5.84	1.73	ns
	9	9.98	0.84	8.08	1.56	ns
	18	5.24	0.83	20.35	2.45	***
CCL2	Control	5.47	1.26	4.06	0.84	ns
	9	10.38	1.29	25.57	5.83	*
	18	9.63	1.16	9.35	2.99	ns
IL-1a	Control	7.18	2.46	5.91	1.34	ns
	9	3.45	0.51	7.11	1.20	*
	18	4.14	0.88	8.86	3.55	ns
IL-6	Control	1.85	0.18	2.33	0.72	ns
	9	29.83	5.67	28.36	4.05	ns
	18	6.58	1.10	9.64	2.77	ns
IL-10	Control	3.31	0.69	2.80	0.89	ns
	9	4.26	1.47	22.78	10.19	ns
	18	3.19	0.81	3.96	1.55	ns
TNF-α	Control	2.43	0.98	0.86	0.32	ns
	9	8.51	2.49	5.59	2.22	ns
	18	2.45	0.64	1.19	0.39	ns
IL-12p70	Control	1.15	0.06	1.02	0.02	ns
	9	1.08	0.04	1.33	0.19	ns
	18	1.28	0.13	1.31	0.15	ns
IL-27	Control	20.41	7.91	17.70	11.50	ns
	9	29.51	14.06	35.37	12.52	ns
	18	21.60	9.80	2.00	0.00	ns
IFN-γ	Control	1.90	0.29	1.36	0.14	ns
	9	56.31	7.17	174.83	25.53	*
	18	15.70	3.15	11.30	2.58	ns
IL-17a	Control	1.38	0.07	1.24	0.05	ns
	9	5.03	0.70	8.13	2.17	ns
	18	2.92	0.53	3.67	1.65	ns

^*Several molecules are up-regulated at day 9 after the EAE induction in both WT and Cxcl17^−/− mice (CCL2, IL-6, TNF-α, IL-27, IFN-γ, and IL-17A) however only CCL2, IL-1α, and IFN-γ showed significant higher production in Cxcl17^−/− mice. At day 18, most of the molecules reduced its production to basal levels, except IL-23 in Cxcl17^−/− mice. Student’s t-test was performed. All values are means ± SEM. Asterisks indicate statistical significance (P < 0.1,

^***P < 0.001). Results are representative from at least 2 individual experiments.