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. 2021 Jun 29;11:575650. doi: 10.3389/fcimb.2021.575650

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Copyright © 2021 Luo, Tang, Yuan, Lin, Mao, Song, Xue, Wu, Ouyang, Hou, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of diagnostic model based on combination of BRE and T-SPOT in Qiaokou cohort. (A) Scatter plots showing the score of diagnostic model based on BRE in ATB patients (n = 1,097) and LTBI individuals (n = 962) in Qiaokou cohort. Horizontal lines indicate the median. ***P < 0.001 (Mann-Whitney U test). Blue dotted lines indicate the cutoff value in distinguishing these two groups. (B) Scatter plots showing ESAT-6 SFC, CFP-10 SFC, and TBAg SFC in ATB patients (n = 1,097) and LTBI individuals (n = 962) in Qiaokou cohort. Horizontal lines indicate the median. ***P < 0.001 (Mann-Whitney U test). (C) ROC analysis showing the performance of ESAT-6 SFC, CFP-10 SFC, TBAg SFC, diagnostic model based on BRE, diagnostic based on combination of BRE and T-SPOT in distinguishing ATB from LTBI in Qiaokou cohort. (D) Venn diagrams showing the overlap of the diagnostic model based on BRE and TBAg SFC in ATB patients (n = 1,097) in Qiaokou cohort. (E) Scatter plots showing the score of diagnostic model based on combination of BRE and T-SPOT in ATB patients (n = 1,097) and LTBI individuals (n = 962) in Qiaokou cohort. Horizontal lines indicate the median. ***P < 0.001 (Mann-Whitney U test). Blue dotted lines indicate the cutoff values in distinguishing these two groups. ATB, active tuberculosis; LTBI, latent tuberculosis infection; ESAT-6, early secreted antigenic target 6; CFP-10, culture filtrate protein 10; TBAg, tuberculosis-specific antigens; SFC, spot-forming cells; AUC, area under the curve; BRE, blood routine examination.