Table 3.
The psychological status and immunologic characteristics in the participants with and without depression-anxiety status after 14 days of treatment.
| Characteristic | Patients with depression-anxiety symptom (N = 20) | Patients without depression -anxiety symptom (N = 37) | P |
|---|---|---|---|
| PHQ-9 | 6.85 (5.26) | 3.43 (4.06) | 0.009 |
| GAD-7 | 5.30 (4.86) | 2.37 (3.11) | 0.008 |
| CD4+/CD8+ | 2.16 (0.95) | 1.87 (0.91) | 0.259 |
| CD3+ | 76.09 (70.21–80.85) | 71.73 (63.35–77.44) | 0.367 |
| CD4+ | 47.61 (8.59) | 41.03 (9.32) | 0.012 |
| CD8+ | 24.52 (6.76) | 24.94 (8.30) | 0.847 |
| IL-2 | 3.73 (3.44–4.42) | 3.88 (3.44–4.50) | 0.913 |
| IL-4 | 3.69 (0.95) | 3.83 (0.97) | 0.593 |
| IL-6 | 7.03 (5.43–10.89) | 6.28 (5.13–8.06) | 0.048 |
| IL-10 | 5.58 (2.14) | 5.66 (1.75) | 0.869 |
| IFN-γ | 3.27 (0.61) | 3.67 (0.73) | 0.048 |
| TNF-α | 3.94 (2.16) | 3.79 (1.53) | 0.764 |
Abbreviations: CD, cluster of differentiation; IL, Interleukin; IFN-γ, Interferon-γ; TNF-α, Tumor Necrosis Factor-α.
Normally distributed data (CD4+/CD8+, CD4+, CD8+, IL-4, IL-10, IFN-γ, TNF-α) were expressed as mean and standard deviation; while data (CD3+, IL-2, IL-6) were expressed as median and interquartile range.
P values indicated the comparison between patients with and without depression-anxiety status.
Differences between two groups were tested using t-test for normally distributed data and the non-normal distributed data were analyzed by Mann-Whitney U test.
The results of cytokines (IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α) are expressed in pg/ml; the results of T cells (CD3+, CD4+, CD8+) are expressed in cells/l.