Table 3. Swansea criteria for the diagnosis of AFLP [5].

Criteria fulfilled – vomiting, abdominal pain, elevated bilirubin, hypoglycemia, elevated transaminases, elevated urea and creatinine, encephalopathy, coagulopathy

ALT: alanine transaminase; AST: aspartate aminotransferase; APTT: activated partial thromboplastin time; AFLP: acute fatty liver of pregnancy.

Swansea criteria

Vomiting

Abdominal pain

Polydipsia/polyuria

Encephalopathy

Elevated bilirubin > 14 µmol/l

Hypoglycemia < 4 mmol/l

Elevated urea > 340 µmol/l

Leukocytosis > 11 x 10⁹ /l

Ascites or bright liver on ultrasound scan

Elevated transaminases (AST or ALT) > 42 IU/l

Elevated ammonia > 47 µmol/l

Renal impairment: creatinine > 150 µmol/l

Coagulopathy: prothrombin time > 14 seconds or APPT > 34 seconds

Micro-vesicular steatosis on liver biopsy